- Title
- Eclampsia in Australia and New Zealand: a prospective population-based study
- Creator
- Pollock, Wendy; Peek, Michael J.; Sullivan, Elizabeth A.; Wang, Alex; Li, Zhuoyang; Ellwood, David; Homer, Caroline S. E.; Jackson Pulver, Lisa; McLintock, Claire; Vaughan, Geraldine; Knight, Marian
- Relation
- NHMRC.510298 http://purl.org/au-research/grants/nhmrc/510298
- Relation
- The Australian and New Zealand Journal of Obstetrics and Gynaecology Vol. 60, Issue 4, p. 533-540
- Publisher Link
- http://dx.doi.org/10.1111/ajo.13100
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2020
- Description
- Background: Eclampsia is a serious consequence of pre-eclampsia. There are limited data from Australia and New Zealand (ANZ) on eclampsia. Aim: To determine the incidence, management and perinatal outcomes of women with eclampsia in ANZ. Materials and Methods: A two-year population-based descriptive study, using the Australasian Maternity Outcomes Surveillance System (AMOSS), carried out in 263 sites in Australia, and all 24 New Zealand maternity units, during a staggered implementation over 2010–2011. Eclampsia was defined as one or more seizures during pregnancy or postpartum (up to 14 days) in any woman with clinical evidence of pre-eclampsia. Results: Of 136 women with eclampsia, 111 (83%) were in Australia and 25 (17%) in New Zealand. The estimated incidence of eclampsia was 2.2 (95% confidence interval (CI) 1.9–2.7) per 10 000 women giving birth. Aboriginal and Torres Strait Islander women were over-represented in Australia (n = 9; 8.1%). Women with antepartum eclampsia (n = 58, 42.6%) were more likely to have a preterm birth (P = 0.04). Sixty-three (47.4%) women had pre-eclampsia diagnosed prior to their first eclamptic seizure of whom 19 (30.2%) received magnesium sulphate prior to the first seizure. Nearly all women (n = 128; 95.5%) received magnesium sulphate post-seizure. No woman received prophylactic aspirin during pregnancy. Five women had a cerebrovascular haemorrhage, and there were five known perinatal deaths. Conclusions: Eclampsia is an uncommon consequence of pre-eclampsia in ANZ. There is scope to reduce the incidence of this condition, associated with often catastrophic morbidity, through the use of low-dose aspirin and magnesium sulphate in women at higher risk.
- Subject
- eclampsia; maternal morbidity; pre-eclampsia; pregnancy; seizure; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1459401
- Identifier
- uon:45665
- Identifier
- ISSN:0004-8666
- Language
- eng
- Reviewed
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